| Month | High (°F) | Low (°F) | Precipitation (in) |
|---|---|---|---|
| January | 40.2 | 21.5 | 2.1 |
| February | 45.6 | 25.3 | 2.3 |
| March | 56.2 | 34.0 | 3.3 |
| April | 67.0 | 43.8 | 4.6 |
| May | 75.6 | 53.7 | 5.4 |
| June | 84.1 | 63.0 | 4.6 |
| July | 88.2 | 66.9 | 4.3 |
| August | 87.0 | 64.8 | 3.8 |
| September | 79.8 | 56.6 | 3.9 |
| October | 68.5 | 44.8 | 3.4 |
| November | 55.0 | 34.4 | 3.3 |
| December | 44.0 | 25.6 | 2.5 |
| Entire Year | 66.0 | 44.5 | 43.5 |
| City | Average (°F) | Record (°F) | Yearly (inches) | |||
|---|---|---|---|---|---|---|
| High | Low | High | Low | Precipitation | Snow | |
| Bolivar | 67.3 | 44.8 | 115 | -25 | 46.6 | n/a |
| Butler | 67.4 | 44.9 | 117 | -26 | 43.3 | 8.0 |
| Cape Girardeau | 68.2 | 47.2 | 107 | -18 | 47.6 | n/a |
| Carrollton | 65.3 | 43.7 | 114 | -34 | 39.6 | 13.1 |
| Clinton | 66.3 | 43.5 | 118 | -31 | 42.9 | 11.1 |
| Columbia | 65.5 | 45.2 | 113 | -26 | 41.3 | 15.9 |
| El Dorado Springs | 67.8 | 45.7 | 114 | -24 | 49.3 | 4.1 |
| Eldon | 66.3 | 46.2 | 115 | -28 | 43.1 | 2.7 |
| Farmington | 66.5 | 44.9 | 114 | -23 | 44.2 | 8.7 |
| Festus | 66.7 | 45.0 | 110 | -27 | 43.2 | 9.8 |
| Hannibal | 62.6 | 43.8 | 114 | -21 | 40.9 | 11.5 |
| Jackson | 68.2 | 47.2 | 112 | -26 | 50.5 | 6.3 |
| Jefferson City | 65.8 | 45.3 | 114 | -25 | 43.2 | 10.7 |
| Joplin | 69.2 | 47.9 | 115 | -21 | 45.2 | n/a |
| Kansas City | 65.1 | 45.0 | 113 | -23 | 39.3 | 17.6 |
| Kirksville | 62.2 | 41.6 | 113 | -31 | 41.8 | 18.3 |
| Lebanon | 67.8 | 46.3 | 113 | -28 | 44.3 | 8.8 |
| Lee's Summit | 65.3 | 45.3 | 109 | -25 | 40.3 | n/a |
| Malden | 69.3 | 49.2 | 112 | -15 | 42.4 | 1.9 |
| Marble Hill | 68.6 | 46.1 | 116 | -31 | 51.0 | 9.4 |
| Marshall | 64.4 | 44.2 | 112 | -26 | 41.2 | 8.5 |
| Marshfield | 66.5 | 46.2 | 110 | -20 | 45.5 | 5.9 |
| Maryville | 62.4 | 40.4 | 113 | -32 | 37.5 | 15.8 |
| Moberly | 64.4 | 44.9 | 112 | -21 | 42.5 | 14.2 |
| Mountain Grove | 65.7 | 45.0 | 110 | -21 | 46.5 | 10.1 |
| Neosho | 68.5 | 46.0 | 112 | -31 | 48.0 | 8.5 |
| Nevada | 67.0 | 46.4 | 117 | -27 | 45.6 | 7.9 |
| Perryville | 66.7 | 44.0 | 110 | -19 | 44.8 | 5.0 |
| Poplar Bluff | 68.9 | 48.3 | 112 | -25 | 50.1 | 6.7 |
| Rolla | 66.5 | 46.2 | 113 | -24 | 47.3 | 17.2 |
| Sedalia | 64.9 | 42.9 | 116 | -30 | 43.2 | 11.2 |
| Sikeston | 68.4 | 48.9 | 111 | -23 | 48.1 | 3.8 |
| Springfield | 67.4 | 46.4 | 113 | -22 | 44.7 | 13.3 |
| St. Charles | 65.5 | 44.8 | 115 | -25 | 44.1 | 7.8 |
| St. Joseph | 65.3 | 42.8 | 110 | -25 | 33.0 | n/a |
| St. Louis | 66.9 | 48.5 | 115 | -18 | 41.7 | 16.5 |
| Trenton | 64.2 | 42.3 | 114 | -26 | 39.6 | 18.2 |
| Vandalia | 63.4 | 43.4 | 108 | -24 | 39.6 | 14.2 |
| Waynesville | 67.8 | 44.4 | 115 | -25 | 46.3 | 6.5 |
| Weldon Spring | 66.0 | 45.0 | 109 | -28 | 43.6 | 12.9 |